What you need to know about Grape Seed Extract

by: Dr. Nathan S. Bryan

Everyone loves grapes. But did you know that one of the healthiest parts of a grape, the seed is often discarded? Grape seeds and grape seed extract have been the focus of many published research studies evaluating their many health benefits, which range from supporting healthy blood pressure levels to providing antioxidant protection and supporting overall cardiovascular health.

Grape seeds

Here are the top four health benefits of grape seed extract based on some of the latest published research studies that excite us the most about the potential benefits of grape seed extract:

    1. Healthy blood pressure – In a recent study published in the British Journal of Nutrition, grape seed extract (GSE) was studied for its potential as a natural ingredient to help support healthy blood pressure. It was a randomized, double-blind, placebo-controlled, study that looked at middle-aged adults with blood pressure in the upper levels of the healthy zone. As a result of this study, grape seed extract was found to be a safe and effective food derived ingredient to support healthy blood pressure levels.


    1. 50x greater antioxidant power – Grape seeds contain not only fats, protein, and carbohydrates, they also contain 5-8% of a category of antioxidants called polyphenols. Polyphenols occur naturally in a variety of plant food sources and have antioxidant properties. Grape seeds contain a subgroup of polyphenols called proanthocyanidins, which have been shown in a number of scientific studies to have an antioxidant power that is 20 times greater than vitamin E and 50 times greater than vitamin C.


    1. Cardiovascular health – A 2013 study evaluated the healthy benefits of a standardized grape seed proanthocyanidin extract in supporting healthy blood pressure levels when associated with non-drug intervention (diet and lifestyle modifications). This study evaluated a 300 mg/day dosage level of grape seed extract (the same level in Nutrient Foundation*), and used blood pressure and heart rate as the primary endpoints. After four months, the results suggested that that the beneficial effects of grape seed extract complement other diet and lifestyle modifications to support cardiovascular health and healthy blood pressure levels.


  1. Nitric Oxide production – Mechanism of action studies on grape seed extract suggest that it may help support an alternative to the conversion of dietary nitrates as a natural mechanism through which the body produces nitric oxide. This is critical, especially as your body ages, to help support overall healthy circulation, blood pressure levels, and cardiovascular health.






Dr. Nathan S. Bryan, HumanN Co-Founder and Nitric Oxide Scientist

Dr. Nathan Bryan, HumanN Co-Founder and Nitric Oxide Scientist, was recruited by the Nobel Laureate, Dr. Ferid Murad to work in the N-O Discovery Program at the University of Texas. It was through this program that Dr. Bryan discovered a safe and natural way to produce Nitric Oxide gas, enabling the body to restore its N-O function. Wanting to bring this technology to the masses, he co-founded Neogenis Laboratories, now HumanN, in 2009.

Dr. Bryan is a recognized world authority in Nitric Oxide research. He is credited with a multitude of significant discoveries in Nitric Oxide function and metabolism, and has published extensively in peer-reviewed scientific journals in the field. He’s been awarded, or has pending, nine patents related to Nitric Oxide. He lectures frequently on Nitric Oxide, and sits on the Board of Directors of the Nitric Oxide Society.

Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his Doctoral degree from Louisiana State University School of Medicine in Shreveport, where he was the recipient of the Dean’s Award for Excellence in Research. He continued his postdoctoral research as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. From there, he continued in academia as a member of faculty in several Texas universities. When not conducting critical research or making significant discoveries for N-O, you can find him at Baylor College of Medicine in the Department of Molecular and Human Genetics where he is also an Adjunct Assistant Professor.

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